Have we found a solution to cure pancreatic cancer, one of our most formidable foes?
P ancreatic malignancies exhibit a multifaceted microenvironment, governing metabolic shifts and fostering a dynamic interplay among diverse cell populations residing in this specialised area. Despite the decade-long endeavours to predominantly elucidate the most lethal pancreatic malignancy, Pancreatic ductal adenocarcinoma (PDAC) continues to stand as one of the most lethal forms of cancer. Adding more concerns, it has been hypothesised that PDAC will overtake colorectal cancer before 2040, moving only behind lung cancer as a leading cause of cancer-related mortality. With almost 97% of oncology trials failing to reach the clinical stage, the dreadful question arises, “Was a solution ever there?”. Cut back through the decades, a hope amidst all odds can be seen, where the culprit cells driving the spread of pancreatic cancer have been identified. Maybe it could be premature enthusiasm to say that we have now found the weakness to target, but a hope is always a hope, and we can be che...