The battle between Mycobacterium tuberculosis and the host can be represented as a game of chess

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The battle between Mtb (Mycobacterium tuberculosis) and the host can be represented as a game of chess:

  1. Mtb's opening move is to deploy its outer membrane proteins to block the host's immune response.

  2. The host responds by activating its complement system to attack Mtb's membrane, forcing it to retreat.

  3. Mtb counterattacks by secreting specialised proteins that manipulate the host's immune cells to prevent them from attacking.

  4. The host retaliates by activating its T-cells, which attack the infected cells, pushing Mtb's pieces back.

  5. Mtb tries to regroup and reposition its pieces by hiding inside the host's macrophages, but the host launches an immune response to destroy the infected cells.

  6. Mtb makes a desperate move by creating granulomas, dense clusters of infected cells, to try to survive the host's attack.

  7. The host sacrifices some of its immune cells to destroy the granulomas and finally checkmates Mtb by eradicating the infection.


Overall, the battle is a strategic back-and-forth struggle between Mtb's ability to evade the host's immune response and the host's efforts to detect and eliminate the infection.


Computational efforts to eradicate latent TB, probably the most lethal subtype of TB due to its hibernating nature, can be found in our recently accepted article 


https://www.sciencedirect.com/science/article/pii/S0079610723000147?via%3Dihub




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